Endocrine Abstracts

Introduction: The standard treatment for differentiated thyroid carcinoma (DTC) with distant metastasis comprises complete total thyroidectomy and lymph node dissection, followed by radioactive iodine (RAI) ablation for metastatic lesions. However, between 2014 and 2015, sorafenib and lenvatinib have been approved for treatment of RAI-refractory advanced thyroid cancer in Japan. We retrospectively analyzed how the treatment results have changed after the approval of tyrosine k...

Introduction: Angiogenesis is known to play an important role in the development, growth, and metastasis of carcinomas. The vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) are major molecules involved in angiogenesis. The VEGF family includes seven members, respectively named VEGF-A (often simply denoted as VEGF), VEGF-B, VEGF-C, VEGF-D, VEGF-E, VEGF-F, and placental growth factor. The VEGFR is a tyrosine kinase receptor with one to three types and is activ...